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carbamazepine will reduce the level or outcome of pirfenidone by influencing hepatic enzyme CYP1A2 metabolism. Contraindicated. Utilization of sturdy CYP1A2 inducers really should be discontinued right before initiating pirfenidone and averted for the duration of cureBlack, tarry stools blistering, peeling, or loosening in the skin upper body pain